Flexner J B, Flexner L B
Proc Natl Acad Sci U S A. 1970 May;66(1):48-52. doi: 10.1073/pnas.66.1.48.
It has previously been shown that expression of memory of maze-learning in mice is blocked by puromycin injected intracerebrally one or more days after the training experience. Bilateral adrenalectomy before training has now been found to protect memory against the effects of puromycin. This protection is absent when adrenalectomy follows training. In view of control experiments, we conclude that adrenalectomy before training modifies factors necessary for the expression of memory and that this alteration makes puromycin ineffective in blocking memory.
先前已经表明，在训练经历后的一天或多天向小鼠脑内注射嘌呤霉素会阻断迷宫学习记忆的表达。现已发现，训练前进行双侧肾上腺切除术可保护记忆免受嘌呤霉素的影响。而训练后进行肾上腺切除术则没有这种保护作用。鉴于对照实验，我们得出结论，训练前进行肾上腺切除术会改变记忆表达所需的因素，并且这种改变使得嘌呤霉素无法有效阻断记忆。
