Rücker G, Tautges J, Sieck A, Wenzl H, Graf E
Arzneimittelforschung. 1978;28(1):7-13.
The known sesquiterpene valeranone (= Yatamanson) was isolated from the subterranian parts of Nardostachys yatamansi (DC). It was pharmacologically investigated in animal experiments of sedative, tranquilizing and antihypertensive properties. In some experiments, typical for tranquilizers, certain activities could be demonstrated such as the prolongation of barbiturate hypnosis, the impairment of rotarod performance, an anticonvulsive activity on electric shock and potentiation of the body-temperature lowering activity of reserpine. In three other pharmacological models an anti-ulcer action was detected. In general the activity of valeranone was lower than those of the standard substances used. As regards the hypotensive property only a weak activity was demonstrated. In toxicological studies on rats and mice an oral LD50 of greater than 3160 mg/kg was found, which suggests the possibility of a therapeutically useful dose ratio.
已知的倍半萜缬草酮（= 雅塔曼松）是从匙叶甘松（DC）的地下部分分离得到的。对其进行了镇静、安神和降压特性的动物实验药理学研究。在一些典型的镇静剂实验中，可以证明某些活性，如延长巴比妥类药物催眠时间、损害转棒试验表现、对电击的抗惊厥活性以及增强利血平的体温降低活性。在另外三种药理学模型中检测到了抗溃疡作用。总体而言，缬草酮的活性低于所使用的标准物质。关于降压特性，仅证明了微弱的活性。在对大鼠和小鼠的毒理学研究中，发现口服半数致死量大于3160毫克/千克，这表明存在治疗有效剂量比的可能性。
