Belova L F, Baginskaia A I, Trumpe T E, Sokolov S Ia, Rybalko K S
Farmakol Toksikol. 1981 Jul-Aug;44(4):463-7.
Inulicin is a sesquiterpene lactone obtained from Inula Japonica L. (Compositae) possesses a fairly wide spectrum of pharmacological action. In doses from 5 to 60 mg/kg it exerts a certain stimulant action on the central nervous system and smooth muscles of the intestine, displays an anti-inflammatory and anti-ulcer activity on pathological models of different genesis, and has capillary-strengthening diuretic properties. When given in low doses, the drug did not affect cardiac activity, while in high doses it might inhibit it. Inulicin is relatively little toxic. The LD50 for mice is 476 mg/kg intraperitoneally and 1330 mg/kg per os.
旋覆花内酯是一种从旋覆花（菊科）中提取的倍半萜内酯，具有相当广泛的药理作用。剂量为5至60毫克/千克时，它对中枢神经系统和肠道平滑肌有一定的兴奋作用，在不同成因的病理模型上表现出抗炎和抗溃疡活性，并且具有增强毛细血管的利尿特性。低剂量给药时，该药物不影响心脏活动，而高剂量时可能会抑制心脏活动。旋覆花内酯毒性相对较小。小鼠腹腔注射的半数致死量为476毫克/千克，口服为1330毫克/千克。
