Männistö P T, Korttila K, Seppälä T
Arzneimittelforschung. 1978;28(1):76-8.
The effect of a single antianxiety dose of chlorpromazine (100 mg) and sulpiride (200 mg) on serum prolactin and gonadotrophins was studied in 6 healthy women in a cross-over study. Another 10 healthy students, 5 women and 5 men, ingested cross-over sulpiride 50 mg t.i.d. for 2 weeks and chlorpromazine 10 mg t.i.d. for 1 week followed by 20 mg t.i.d. for the second week, and serum prolactin levels were measured on the 7th and 14th day after the beginning of the treatment. In acute study sulpiride caused a fivefold increase in serum prolactin at 1 h. Chlorpromazine induced a slower and smaller increase. Prolactin concentrations remained raised for at least 6 h. The initial raised prolactin concentration induced by sulpiride was associated with antidiuresis. The only change in gonadotrophins was the decrease of serum LH caused by chlorpromazine at 3 h. Subchronic administration of sulpiride (50 mg t.i.d.) caused in both sexes a significantly (P less than 0.05 to 0.01) greater increase of prolactin than did chlorpromazine (10 or 20 mg t.i.d.). It is concluded that in doses useful in the treatment of neurotic patients sulpiride causes a greater increase in serum prolactin levels than does chlorpromazine.
在一项交叉研究中，对6名健康女性给予单剂量抗焦虑药物氯丙嗪（100毫克）和舒必利（200毫克），研究其对血清催乳素和促性腺激素的影响。另外10名健康学生，5名女性和5名男性，交叉服用舒必利50毫克每日三次，持续2周，氯丙嗪10毫克每日三次，持续1周，第二周改为20毫克每日三次，并在治疗开始后的第7天和第14天测量血清催乳素水平。在急性研究中，舒必利在1小时时使血清催乳素增加了五倍。氯丙嗪引起的增加较慢且幅度较小。催乳素浓度至少在6小时内持续升高。舒必利引起的初始催乳素浓度升高与抗利尿作用有关。促性腺激素的唯一变化是氯丙嗪在3小时时导致血清促黄体生成素降低。舒必利（50毫克每日三次）的亚慢性给药在男女两性中引起的催乳素升高均显著（P小于0.05至0.01）大于氯丙嗪（10或20毫克每日三次）。得出的结论是，在治疗神经症患者有效的剂量下，舒必利比氯丙嗪更能使血清催乳素水平大幅升高。
