Ruiz E, Ortega E, Mendoza C, Osorio C
Rev Esp Fisiol. 1984 Jun;40(2):243-8.
In order to study the effects of prolactin upon the gonadotrophins and steroid hormones, hyperprolactinaemia was induced by the administration of sulpiride. 12 men between the ages of 18 and 20 were given 3 capsules of 50 mg of sulpiride daily for a period of 15 days, and the following parameters being measured before and after the treatment: (prolactine, FSH, LH, testosterone, estradiol, ACTH and DHEA-S) by RIA, (cortisol) by fluorimetry and (etiocholanone, androsterone, pregnandiol, pregnantriol, pregnantriolone, 11-keto etiocholanone and 11-OH androsterone) by gas chromatography. Our results show that on termination of the treatment there was a significant rise in the prolactin and DHEA-S serum levels and a drop in the FSH serum levels but not of LH. In addition there was a marked increase in all the androgen levels studied, (etiocholanone, androsterone and 11-keto etiocholanone) with the exception of testosterone.
为了研究催乳素对促性腺激素和类固醇激素的影响，通过给予舒必利诱导高催乳素血症。12名年龄在18至20岁之间的男性每天服用3粒50毫克的舒必利胶囊，持续15天，并在治疗前后测量以下参数：采用放射免疫分析法测定（催乳素、促卵泡生成素、促黄体生成素、睾酮、雌二醇、促肾上腺皮质激素和硫酸脱氢表雄酮），采用荧光分析法测定（皮质醇），采用气相色谱法测定（本胆烷醇酮、雄酮、孕二醇、孕三醇、孕三酮、11-酮本胆烷醇酮和11-羟基雄酮）。我们的结果表明，治疗结束时，血清催乳素和硫酸脱氢表雄酮水平显著升高，血清促卵泡生成素水平下降，但促黄体生成素水平未下降。此外，除睾酮外，所有研究的雄激素水平（本胆烷醇酮、雄酮和11-酮本胆烷醇酮）均显著升高。
