Shubber A H, Lloyd S, Soulsby E J
Z Parasitenkd. 1984;70(2):219-28. doi: 10.1007/BF00942225.
Specific antigen-induced lymphocyte transformation in vitro and haemagglutinating antibody responses were absent from lambs infected with Haemonchus contortus. However, when lambs were injected with soluble third stage larval antigen of H. contortus, given on five occasions during the first 6 weeks of life, specific antigen-induced lymphocyte transformation and haemagglutinating antibodies were induced to the antigen. In particular, a periparturient increased susceptibility to infection and the resultant presence of heavy infections with H. contortus in ewes appeared to prime their lambs to respond and marked lymphocyte transformation was observed in antigen injected lambs born of heavily infected ewes. The enhancement of this response was associated with the colostral transfer of as yet unidentified factors. The superimposition of an infection with H. contortus in lambs which had been stimulated to respond to antigen, suppressed the in vitro responsiveness of their lymphocytes. Although individual variation was apparent, a direct correlation between the presence of in vitro antigen-induced lymphocyte transformation to third stage larval antigen and susceptibility to infection occurred.
感染捻转血矛线虫的羔羊体外不存在特异性抗原诱导的淋巴细胞转化和血凝抗体反应。然而，在羔羊出生后的前6周内分5次给其注射捻转血矛线虫可溶性三期幼虫抗原后，可诱导产生针对该抗原的特异性抗原诱导的淋巴细胞转化和血凝抗体。特别是，围产期母羊对感染的易感性增加以及由此导致的捻转血矛线虫重度感染，似乎使它们的羔羊能够产生反应，在由重度感染母羊所生的注射了抗原的羔羊中观察到明显的淋巴细胞转化。这种反应的增强与初乳中尚未确定的因子的传递有关。在已被刺激对抗原产生反应的羔羊中叠加捻转血矛线虫感染，会抑制其淋巴细胞的体外反应性。尽管个体差异明显，但体外抗原诱导的针对三期幼虫抗原的淋巴细胞转化的存在与感染易感性之间存在直接相关性。
