Winsnes R, Frøland S S, Degré M I
Scand J Infect Dis. 1978;10(1):21-7. doi: 10.3109/inf.1978.10.issue-1.05.
Immunotherapy was given to 13 patients suffering from lymphoproliferative diseases complicated by varicella-zoster (VZ) infection. Five patients received transfer factor (TF) only, 6 received TF and zoster immunoglobulin (ZIG), and 2 received ZIG only. ZIG did not seem to alter the course of the infection. Cessation of vesicle formation and initiation of crust formation took place within 1 day after the first injection of TF in 5 patients with a localized zoster. In 4 patients suffering from an early dissemination of VZ infection, cessation of vesicle formation took place within 1 day (1 patient), 2 days (1 patient), 3 days (1 patient) or 4 days (1 patient) after the first injection of TF. An increase in serum interferon was observed in 4 of 9 patients who received TF, while no increase in serum interferon was observed in the control groups. Administration of a high-titer ZIG preparation did not seem to depress the humoral antibody response when combined with TF therapy. Therapy with TF in combination with ZIG seemed to have a beneficial effect in patients with malignancy when administered early in the acute VZ infection.
对13例患有淋巴增生性疾病并发水痘 - 带状疱疹（VZ）感染的患者进行了免疫治疗。5例患者仅接受转移因子（TF），6例接受TF和带状疱疹免疫球蛋白（ZIG），2例仅接受ZIG。ZIG似乎并未改变感染进程。5例局限性带状疱疹患者在首次注射TF后1天内水疱形成停止并开始结痂。4例患有早期VZ感染播散的患者，在首次注射TF后1天（1例）、2天（1例）、3天（1例）或4天（1例）内水疱形成停止。在接受TF的9例患者中，有4例观察到血清干扰素增加，而对照组未观察到血清干扰素增加。当与TF疗法联合使用时，高滴度ZIG制剂的给药似乎并未抑制体液抗体反应。在急性VZ感染早期给予TF联合ZIG治疗似乎对恶性肿瘤患者有有益效果。
