Patel P A, Yoonessi S, O'Malley J, Freeman A, Gershon A, Ogra P L
J Pediatr. 1979 Feb;94(2):223-30. doi: 10.1016/s0022-3476(79)80828-8.
Normal subjects and patients with lymphoma or leukemia were tested for the levels of lymphocytes, E-rosette--forming T-cells, serum and vesicle fluid interferon, and specific in vitro proliferative response to varicella-zoster antigen after clinical varicella or herpes zoster illness. The effect of polyinosinic acid/polycytidilic acid on the immune response was also evaluated. The development of VZ specific cell-mediated response in normal subjects was characterized by intense proliferative activity eight to ten days after the onset of illness, with significant decline 70 to 80 days later. The responses in subjects with lymphoma or leukemia were much lower. Few subjects with chickenpox or zoster with lymphoma or leukemia died during the infection. Death was associated with significant depletion of E-rosette--forming T-cells, and grossly deficient specific cellular response to VZ antigen. Treatment with Poly IC frequently induced elevations in serum as well as vesicle fluid interferon levels, and increased the proliferative activity of lymphocytes against VZ antigen.
对正常受试者以及淋巴瘤或白血病患者进行检测，测定其淋巴细胞、E 花环形成 T 细胞、血清和囊泡液干扰素水平，以及在临床水痘或带状疱疹发病后对水痘 - 带状疱疹抗原的特异性体外增殖反应。还评估了聚肌苷酸/聚胞苷酸对免疫反应的影响。正常受试者中水痘 - 带状疱疹特异性细胞介导反应的发展特点是发病后八至十天出现强烈的增殖活性，70 至 80 天后显著下降。淋巴瘤或白血病患者的反应则低得多。很少有患水痘或带状疱疹的淋巴瘤或白血病患者在感染期间死亡。死亡与 E 花环形成 T 细胞的显著耗竭以及对水痘 - 带状疱疹抗原的特异性细胞反应严重不足有关。聚肌苷酸胞嘧啶核苷酸（Poly IC）治疗常常导致血清以及囊泡液干扰素水平升高，并增加淋巴细胞对水痘 - 带状疱疹抗原的增殖活性。
