Iravani J, Melville G N, Horstmann G
Arzneimittelforschung. 1978;28(2):250-4.
The effect of N-acetylcysteine on mucus trasnport velocity (MV), ciliary beat frequency (CBF), mucus production (MP), mucus lysis and on the micro-morphology of the secretory cells was studied in mammalian airways. The results showed that: 1. MV increased in healthy rats and rabbits, as well as in bronchitic rats, after concentrations as low as 10(-14) g/ml. Depression of MV occurred first at 10(-6) and 10(-5) g/ml in healthy and bronchitic animals, respectively. 2. CBF was stimulated at concentrations between 10(-12) and 10(-10) g/ml and decreased at concentrations above 10(-8) g/ml. 3. MP increased by approximately 100% over control values. 4. Lysis of stagnant mucus was evident first at a concentration of 10(-11) g/ml after 15 min incubation. 5. TEM confirmed the increased activity of the mucus secreting cells and showed that no pathological changes occurred within the cell following incubation at 10(-7) g/ml for up to 150 min. The importance of these findings on the overall mucociliary function is discussed.
研究了N-乙酰半胱氨酸对哺乳动物气道黏液转运速度（MV）、纤毛摆动频率（CBF）、黏液分泌（MP）、黏液溶解以及分泌细胞微观形态的影响。结果表明：1. 在健康大鼠和兔子以及患支气管炎的大鼠中，低至10(-14) g/ml的浓度后MV增加。在健康动物和患支气管炎的动物中，MV分别在10(-6)和10(-5) g/ml时首次出现下降。2. 在10(-12)至10(-10) g/ml的浓度范围内CBF受到刺激，而在高于10(-8) g/ml的浓度时CBF下降。3. MP比对照值增加了约100%。4. 孵育15分钟后，在10(-11) g/ml的浓度下首次明显出现停滞黏液的溶解。5. 透射电子显微镜（TEM）证实了黏液分泌细胞的活性增加，并表明在10(-7) g/ml孵育长达150分钟后细胞内未发生病理变化。讨论了这些发现对整体黏液纤毛功能的重要性。
