Mahn I, Moeller R M, Müller-Berghaus G
Thromb Haemost. 1978 Feb 28;39(1):32-8.
16 non-pregnant female and 19 pregnant rabbits were injected with purified rabbit 125I-fibrinogen in order to study the catabolism of fibrinogen before and after delivery. The half-life time (T 1/2) of the clottable 125I-radioactivity in pregnant rabbits during the last third of gestation was 27.3 +/- 5.3 hr in comparison to 54.4 +/- 3.7 hr in non-pregnant rabbits. After delivery, T 1/2 returned to normal values of 47.9 +/- 10.9 hr. The fractional catabolic rate (FCR) of the clotabble 125I-radioactivity was 67.1% X d-1 +/- 8.6 before and 41.6% X d-1 after delivery whereas FCR in non-pregnant rabbits amounted to 44.7% X d-1 +/- 4.8. These figures demonstrate a pronounced increase in fibrinogen catabolism during the last third of gestation in pregnant rabbits and a normalization immediately after delivery. Although in pregnant rabbits the elimination of fibrinogen from the circulating blood was pronouncedly increased, the plasma fibrinogen concentration did not change. Only after delivery did the fibrinogen concentration increase when the fibrinogen catabolism had already normalized.
为研究分娩前后纤维蛋白原的分解代谢情况，给16只未孕雌性兔子和19只怀孕兔子注射了纯化的兔125I - 纤维蛋白原。妊娠最后三分之一阶段，怀孕兔子中可凝125I放射性的半衰期（T 1/2）为27.3±5.3小时，而未孕兔子为54.4±3.7小时。分娩后，T 1/2恢复到47.9±10.9小时的正常水平。可凝125I放射性的分解代谢率（FCR）在分娩前为67.1%×d -1±8.6，分娩后为41.6%×d -1，而未孕兔子的FCR为44.7%×d -1±4.8。这些数据表明，怀孕兔子在妊娠最后三分之一阶段纤维蛋白原分解代谢显著增加，分娩后立即恢复正常。尽管怀孕兔子循环血液中纤维蛋白原的清除明显增加，但血浆纤维蛋白原浓度并未改变。只有在分娩后，当纤维蛋白原分解代谢已经恢复正常时，纤维蛋白原浓度才会增加。
