Müller-Berghaus G, Moeller R M, Mahn I
Am J Obstet Gynecol. 1978 Jul 15;131(6):655-60. doi: 10.1016/0002-9378(78)90827-x.
Although thrombin-mediated fibrinogen derivatives have been observed in normal pregnancy, an increased turnover of fibrinogen has been suspected but has not yet been demonstrated. Fibrinogen turnover was studied in 14 pregnant and 10 nonpregnant female rabbits by use of purified rabbit 125I-labeled fibrinogen. In the last third of gestation the half life of fibrinogen was shortened by 45% and the fractional catabolic rate increased by 44% in comparison to the values for the first third of gestation obtained in the same rabbits. The distribution volume of the injected fibrinogen representing the plasma volume increased by a mean of 18% during gestation. Fibrinogen concentration did not change during gestation. From a comparison of the measured data from the first and last thirds of gestation, it can be calculated that the synthesis rate of fibrinogen increased by about 80%. Furthermore, a positive correlation was found between the number of young per litter and the acceleration of fibrinogen elimination, indicating that a local process of intravascular coagulation in the placenta is responsible for the accelerated turnover of fibrinogen during gestation.
虽然在正常妊娠中已观察到凝血酶介导的纤维蛋白原衍生物，但人们怀疑纤维蛋白原的周转率增加，但尚未得到证实。通过使用纯化的兔125I标记纤维蛋白原，对14只怀孕的雌性兔和10只未怀孕的雌性兔进行了纤维蛋白原周转率研究。与同一批兔子妊娠前三分之一时获得的值相比，在妊娠后三分之一时，纤维蛋白原的半衰期缩短了45%，分解代谢率增加了44%。代表血浆容量的注入纤维蛋白原的分布容积在妊娠期间平均增加了18%。妊娠期间纤维蛋白原浓度没有变化。通过比较妊娠前三分之一和后三分之一的测量数据，可以计算出纤维蛋白原的合成率增加了约80%。此外，每窝幼崽数量与纤维蛋白原清除加速之间存在正相关，这表明胎盘内的局部血管内凝血过程是妊娠期间纤维蛋白原周转率加快的原因。
