McGovern A J, Makanjuola R, Arbuthnott G W, Loudon J B, Glen A I
Acta Pharmacol Toxicol (Copenh). 1978 Apr;42(4):259-63. doi: 10.1111/j.1600-0773.1978.tb02198.x.
Severe neurotoxicity has been reported in patients receiving combinations of lithium and butyrophenones and halogenated phenothiazines and the suggestion has been made that lithium is preferentially concentrated in dopamine systems in brain. Conventional flame atomic absorption spectrophotometry does not allow analysis of sufficiently small samples of brain tissue to allow accurate association with specific transmitter systems, although previous reports have suggested that lithium is concentrated in the striatum. A method has been developed using flameless atomic absorption spectrophotometry to allow accurate measurement of lithium concentrations in 10--100 ng fresh weight of brain tissue. Using this technique in experiments where rats were fed lithium over a period of three weeks, we could not confirm a direct association of lithium with an area predominetly served by dopamine transmitters.
据报道，接受锂盐与丁酰苯类及卤代吩噻嗪类药物联合治疗的患者会出现严重的神经毒性，有人提出锂盐在大脑的多巴胺系统中会优先蓄积。传统的火焰原子吸收分光光度法无法对足够小的脑组织样本进行分析，以准确关联特定的递质系统，尽管先前的报告表明锂盐在纹状体中蓄积。已开发出一种使用无火焰原子吸收分光光度法的方法，可精确测量10-100纳克鲜重脑组织中的锂浓度。在大鼠连续三周喂食锂盐的实验中使用该技术，我们无法证实锂盐与主要由多巴胺递质支配的区域有直接关联。
