Faber O K, Thomsen M, Binder C, Platz P, Svejgaard A
Acta Endocrinol (Copenh). 1978 Jun;88(2):329-38. doi: 10.1530/acta.0.0880329.
In a family with maturity-onset type of diabetes mellitus inherited as a dominant, autosomal trait (MODY), the HLA genotypes were compared with the glucose tolerance and the plasma insulin response to oral glucose. In the members with impaired glucose tolerance, the plasma insulin response was of the insulino-tardic type, while those with normal or borderline glucose tolerance had a normal plasma insulin response. HLA tissue typing for A, B, C and D series antigens carried out in 19 of the members showed no association between specific HLA antigens and imparied glucose tolerance. Moreover, when analysing the segregation of the disease and the HLA characters, several recombinants between MODY and HLA would have to be postulated if the gene(s) for this form of diabetes mellitus should be closely linked to the HLA locus.
在一个以显性常染色体性状遗传的成年发病型糖尿病（MODY）家族中，对HLA基因型与葡萄糖耐量以及口服葡萄糖后的血浆胰岛素反应进行了比较。在葡萄糖耐量受损的成员中，血浆胰岛素反应呈胰岛素延迟型，而葡萄糖耐量正常或临界的成员血浆胰岛素反应正常。对19名成员进行的A、B、C和D系列抗原的HLA组织分型显示，特定的HLA抗原与葡萄糖耐量受损之间没有关联。此外，在分析疾病和HLA特征的分离情况时，如果这种糖尿病的基因与HLA位点紧密连锁，就必须假定MODY和HLA之间存在几个重组体。
