Lendrum R, Walker G, Cudworth A G, Woodrow J C, Gamble D R
Br Med J. 1976 Jun 26;1(6025):1565-7. doi: 10.1136/bmj.1.6025.1565.
In a random series of 139 insulin-dependent diabetics aged 30 or under at the onset of disease islet-cell antibody (ICA) was detected in 33 cases (24%). In 27 patients who had had diabetes for less than one year 16 (59%) had ICA. Only one out of 51 patients with maturity onset diabetes who were not dependent on insulin were positive for ICA. Four out of 19 patients with late onset insulin-dependent diabetes had ICA. There was no association between the presence of ICA and any particular HLA phenotype. Within families containing two or more HLA haploidentical siblings with juvenile onset diabetes ICA was a variable finding both in its occurrence and in its relation to the duration of disease. A possible mode of action for the HLA-linked gene may be to permit a rapid immunological destructive process, possibly associated with viral infection.
在一组随机挑选的139例发病时年龄在30岁及以下的胰岛素依赖型糖尿病患者中，33例（24%）检测到胰岛细胞抗体（ICA）。在病程不到一年的27例患者中，16例（59%）有ICA。在51例非胰岛素依赖型成年发病糖尿病患者中，只有1例ICA呈阳性。19例迟发性胰岛素依赖型糖尿病患者中有4例有ICA。ICA的存在与任何特定的HLA表型之间均无关联。在有两名或更多HLA单倍型相同的青少年发病糖尿病同胞的家庭中，ICA在其出现情况以及与病程的关系方面都是一个可变的发现。与HLA相关的基因可能的作用方式是允许一个快速的免疫破坏过程，这可能与病毒感染有关。
