胃内pH值对麻醉且使用阿托品的十二指肠溃疡患者及对照组胃窦胃泌素和生长抑素释放的影响。
Effect of intragastric pH on antral gastrin and somatostatin release in anaesthetised, atropinised duodenal ulcer patients and controls.
作者信息
Jensen S L, Holst J J, Christiansen L A, Shokouh-Amiri M H, Lorentsen M, Beck H, Jensen H E
出版信息
Gut. 1987 Feb;28(2):206-9. doi: 10.1136/gut.28.2.206.
The synchronous change in the antral release of gastrin and somatostatin into a vein draining the stomach was studied during acidic and alkaline intragastric pH in six anaesthetised duodenal ulcer patients and six controls after atropinisation. No differences in the basal secretion of gastrin and somatostatin were observed among the two groups. Alkaline as well as acidic intragastric pH had no effect on the antral release of somatostatin in duodenal ulcer patients and controls. In contrast, alkaline intragastric pH was associated with a significantly higher antral gastrin release in duodenal ulcer patients than in controls. Acidic intragastric pH was associated with a significantly smaller inhibition of antral gastrin release in duodenal ulcer patients than in controls. These results suggest that atropinised anaesthetised duodenal patients release gastrin abnormally in the presence of acidic or alkaline intragastric pH and that any inverse relationship between antral gastrin and somatostatin release is uncoupled under these conditions.
在六名麻醉状态下的十二指肠溃疡患者和六名阿托品化后的对照者中，研究了胃内pH值呈酸性和碱性时，胃窦部胃泌素和生长抑素向引流胃的静脉内释放的同步变化。两组之间胃泌素和生长抑素的基础分泌未观察到差异。胃内pH值呈碱性以及酸性时，十二指肠溃疡患者和对照者的胃窦部生长抑素释放均无影响。相反，胃内pH值呈碱性时，十二指肠溃疡患者胃窦部胃泌素释放显著高于对照者。胃内pH值呈酸性时，十二指肠溃疡患者胃窦部胃泌素释放受抑制程度显著小于对照者。这些结果表明，阿托品化的麻醉十二指肠患者在胃内pH值呈酸性或碱性时胃泌素释放异常，并且在这些条件下胃窦部胃泌素和生长抑素释放之间的任何反向关系均被解除。
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