Balint J A, Kyriakides E C, Gunawardhane G D, Risenberg H
Pediatr Res. 1978 Jun;12(6):715-9. doi: 10.1203/00006450-197806000-00008.
In order to evaluate the role of surfactant lecithin composition in the development of the infantile respiratory distress syndrome (IRDS) we have examined lecithin fatty acid composition from gastric aspirates obtained at the time of delivery from 14 full term healthy infants, 9 control premature infants without respiratory distress, and 16 premature infants who developed IRDS. The latter had significantly reduced concentrations of palmitic acid (48.4 +/- 1.8% vs. 65.3 +/- 1.5% in fullterm and 59.5 +/- 0.8% in control premature infants, P less than 0.001). None of the infants in whom palmitic acid was more than 60% of total lecithin fatty acids developed IRDS, whereas 10 of 11 infants with values below 50% did develop this complication. Lecithin from gastric aspirate was shown to be similar in fatty acid composition to lecithins from tracheal washings and amniotic fluid. Palmitic acid concentrations in lecithins of serial tracheal washings paralleled the clinical course of eight infants with IRDS.
为了评估表面活性物质卵磷脂成分在婴儿呼吸窘迫综合征（IRDS）发病中的作用，我们检测了14名足月健康婴儿、9名无呼吸窘迫的对照早产儿以及16名患IRDS的早产儿在分娩时获得的胃吸出物中的卵磷脂脂肪酸成分。后者的棕榈酸浓度显著降低（足月婴儿为48.4±1.8%，对照早产儿为59.5±0.8%，而患IRDS的早产儿为65.3±1.5%，P<0.001）。棕榈酸占总卵磷脂脂肪酸60%以上的婴儿均未发生IRDS，而棕榈酸值低于50%的11名婴儿中有10名发生了这种并发症。胃吸出物中的卵磷脂在脂肪酸组成上与气管冲洗液和羊水的卵磷脂相似。8名患IRDS婴儿的系列气管冲洗液中卵磷脂的棕榈酸浓度与临床病程平行。
