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Concentrations of (3)H-nicotine in the superior cervical and nodose ganglia of anaesthetized cats were measured after close-arterial injection.2. Shortly after injection there was a higher concentration of (3)H-nicotine in the superior cervical ganglion than in the nodose ganglion. Mean concentration ratios, superior cervical ganglion/nodose ganglion (S/N ratios) were: 2 min after injection, 1.60 +/- 0.19; 4 min, 1.21 +/- 0.19; 8 min, 0.92 +/- 0.05. These ratios were independent of the dose of nicotine over the range 4 to 200 mug in 0.2 ml.3. There was no comparable difference in the concentrations of injected (14)C-inulin or (3)H(2)O in the two ganglia, or in total water content.4. Procedures which reduced the pharmacological action of nicotine (pre-treatment with hexamethonium, admixture of (14)C-inulin) tended to reduce the S/N ratio for nicotine.5. Autoradiographs showed that nicotine entered the neurones of both superior cervical and nodose ganglia.6. It was concluded that the higher concentration of nicotine in the superior cervical ganglion was probably related to its selective pharmacological action at this site, and may have been due to a greater intracellular retention of nicotine.

在麻醉猫的颈上神经节和结状神经节中，经动脉近端注射后测量了（3）H-尼古丁的浓度。
注射后不久，颈上神经节中（3）H-尼古丁的浓度高于结状神经节。颈上神经节/结状神经节的平均浓度比（S/N比）为：注射后2分钟，1.60±0.19；4分钟，1.21±0.19；8分钟，0.92±0.05。在0.2毫升中4至200微克的尼古丁剂量范围内，这些比值与尼古丁剂量无关。
在两个神经节中，注射的（14）C-菊粉或（3）H2O的浓度以及总含水量没有可比的差异。
降低尼古丁药理作用的程序（六甲铵预处理、（14）C-菊粉混合）倾向于降低尼古丁的S/N比。
放射自显影片显示尼古丁进入了颈上神经节和结状神经节的神经元。
得出的结论是，颈上神经节中尼古丁浓度较高可能与其在该部位的选择性药理作用有关，可能是由于尼古丁在细胞内的保留更多。

Concentrations of (3)H-nicotine in the superior cervical and nodose ganglia of anaesthetized cats were measured after close-arterial injection.2. Shortly after injection there was a higher concentration of (3)H-nicotine in the superior cervical ganglion than in the nodose ganglion. Mean concentration ratios, superior cervical ganglion/nodose ganglion (S/N ratios) were: 2 min after injection, 1.60 +/- 0.19; 4 min, 1.21 +/- 0.19; 8 min, 0.92 +/- 0.05. These ratios were independent of the dose of nicotine over the range 4 to 200 mug in 0.2 ml.3. There was no comparable difference in the concentrations of injected (14)C-inulin or (3)H(2)O in the two ganglia, or in total water content.4. Procedures which reduced the pharmacological action of nicotine (pre-treatment with hexamethonium, admixture of (14)C-inulin) tended to reduce the S/N ratio for nicotine.5. Autoradiographs showed that nicotine entered the neurones of both superior cervical and nodose ganglia.6. It was concluded that the higher concentration of nicotine in the superior cervical ganglion was probably related to its selective pharmacological action at this site, and may have been due to a greater intracellular retention of nicotine.

在麻醉猫的颈上神经节和结状神经节中，经动脉近端注射后测量了（3）H-尼古丁的浓度。
注射后不久，颈上神经节中（3）H-尼古丁的浓度高于结状神经节。颈上神经节/结状神经节的平均浓度比（S/N比）为：注射后2分钟，1.60±0.19；4分钟，1.21±0.19；8分钟，0.92±0.05。在0.2毫升中4至200微克的尼古丁剂量范围内，这些比值与尼古丁剂量无关。
在两个神经节中，注射的（14）C-菊粉或（3）H2O的浓度以及总含水量没有可比的差异。
降低尼古丁药理作用的程序（六甲铵预处理、（14）C-菊粉混合）倾向于降低尼古丁的S/N比。
放射自显影片显示尼古丁进入了颈上神经节和结状神经节的神经元。
得出的结论是，颈上神经节中尼古丁浓度较高可能与其在该部位的选择性药理作用有关，可能是由于尼古丁在细胞内的保留更多。

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