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三氯乙烯作业工人的染色体研究(作者译)

[Chromosome studies on trichloroethylene workers (author's transl)].

作者信息

Konietzko H, Haberlandt W, Heilbronner H, Reill G, Weichardt H

出版信息

Arch Toxicol. 1978 Jun 16;40(3):201-6. doi: 10.1007/BF00364651.

DOI:10.1007/BF00364651
PMID:581058
Abstract

On the basis of lymphocyte cultures, chromosome studies were carried out on 28 degreasers under different trichloroethylene load. Nine of these cases showed pathological rates of hypodiploid cells, but otherwise normal caryotypes; one case had a caryotype 47,XY,+mar (small metacentric extrachromosome). In these nine cases the trichloroethylene load, but not the exposure periods on the working place were significantly higher than in the control group.

摘要

基于淋巴细胞培养,对28名处于不同三氯乙烯负荷下的脱脂工人进行了染色体研究。其中9例显示亚二倍体细胞的病理率,但核型其他方面正常;1例核型为47,XY,+mar(小的中着丝粒额外染色体)。在这9例中,三氯乙烯负荷显著高于对照组,但在工作场所的暴露时间并非如此。

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1
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引用本文的文献

1
Epoxides--is there a human health problem?环氧化合物——存在人类健康问题吗?
Br J Ind Med. 1980 Nov;37(4):317-36. doi: 10.1136/oem.37.4.317.
2
Trichloroethylene vapours do not produce dominant lethal mutations in male mice.三氯乙烯蒸汽不会在雄性小鼠中产生显性致死突变。
Arch Toxicol. 1980 May;45(1):37-44. doi: 10.1007/BF00303293.
3
Interactions of trichloroethylene with DNA in vitro and with RNA and DNA of various mouse tissues in vivo.三氯乙烯在体外与DNA以及在体内与各种小鼠组织的RNA和DNA的相互作用。

本文引用的文献

1
Chromosome preparations of leukocytes cultured from human peripheral blood.从人外周血培养的白细胞的染色体标本制备。
Exp Cell Res. 1960 Sep;20:613-6. doi: 10.1016/0014-4827(60)90138-5.
2
Carcnogenicity of epoxides, lactones, and peroxy compounds. VI. Structure and carcinogenic activity.环氧化物、内酯及过氧化物的致癌性。VI. 结构与致癌活性
J Natl Cancer Inst. 1967 Dec;39(6):1217-28.
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Arztl Forsch. 1971 Jul 10;25(7):218-23.
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Sister chromatid exchanges in peripheral lymphocytes of workers exposed to benzene, trichloroethylene, or tetrachloroethylene, with reference to smoking habits.接触苯、三氯乙烯或四氯乙烯的工人外周血淋巴细胞姐妹染色单体交换情况,与吸烟习惯的关系
Int Arch Occup Environ Health. 1990;62(2):171-6. doi: 10.1007/BF00383594.
4
[Field studies in solvent factories. I. Measuring methods for the examination of MAK values in various trichloroethylene washing plants].[溶剂厂实地研究。I. 各类三氯乙烯清洗厂中MAK值检测方法]
Zentralbl Arbeitsmed. 1972 Nov;22(11):323-32.
5
Background information on trichloroethylene.三氯乙烯的背景信息。
J Occup Med. 1975 Sep;17(9):603-5.
6
Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation.作为代谢环氧乙烷形成的函数,氯乙烯的体外诱变性和潜在致癌性。
Biochem Pharmacol. 1975 Nov 1;24(21):2013-7. doi: 10.1016/0006-2952(75)90396-2.
7
Industrial mutagens and potential mutagens I. Halogenated aliphatic derivatives.工业诱变剂和潜在诱变剂I. 卤代脂肪族衍生物
Mutat Res. 1976;32(3-4):267-307. doi: 10.1016/0165-1110(76)90003-8.
8
Carcinogenicity of trichloroethylene: fact or artifact?三氯乙烯的致癌性:事实还是假象?
Arch Toxicol. 1977 Jul 19;37(3):233-6. doi: 10.1007/BF00355492.