抗甲状腺素抗体导致血清甲状腺素水平降低。

Low serum thyroxine due to anti-thyroxine antibody.

作者信息

Ikekubo K, Konishi J, Nakajima K, Endo K, Mori T, Torizuka K

出版信息

Endocrinol Jpn. 1978 Jun;25(3):275-9. doi: 10.1507/endocrj1954.25.275.

DOI:10.1507/endocrj1954.25.275

Abstract

In one case of untreated Hashimoto's thyroiditis, the serum thyroxine (T4) value, obtained by radioimmunoassay (RIA) employing resin to separate bound and free T4, was significantly lower than that obtained by competitive protein binding analysis (CPBA). The discrepancy was found to be due to the presence of anti-thyroxine autoantibody in the serum. This phenomenon is considered to be of practical importance in interpreting the T4 value by RIA in cases with autoimmune thyroid diseases.

摘要

在一例未经治疗的桥本甲状腺炎患者中，采用树脂分离结合型和游离型甲状腺素的放射免疫分析法（RIA）测得的血清甲状腺素（T4）值，显著低于竞争性蛋白结合分析法（CPBA）测得的值。发现这种差异是由于血清中存在抗甲状腺素自身抗体。这种现象被认为在解释自身免疫性甲状腺疾病患者通过RIA测得的T4值时具有实际重要性。