Kane P B, Lane B P, Cordice J W, Greenberg G M
Arch Pathol Lab Med. 1978 Dec;102(12):618-22.
Pulmonary lymphangiomyomatosis occurs almost exclusively in women and is characterized by a widespread proliferation of spindle-shaped cells within the lung. Although these cells have been considered to be vessel-associated smooth muscle cells, their origin remains undefined. In this case of pulmonary lymphangiomyomatosis studied by electron microscopy, the proliferating cells were found to vary morphologically and to differ from typical smooth muscle cells. The ultrastructure suggests that the cell of origin might be the pulmonary interstitial cell rather than vascular smooth muscle. It is also possible that the cells are derived from pericytes. Accumulations of glycogen were seen in the proliferating cells and are suggested to be a reflection of an estrogenic hormonal dominance.
肺淋巴管肌瘤病几乎仅发生于女性，其特征为肺内梭形细胞广泛增殖。尽管这些细胞被认为是与血管相关的平滑肌细胞，但其起源仍不明确。在这例通过电子显微镜研究的肺淋巴管肌瘤病中，发现增殖细胞在形态上存在差异，且与典型的平滑肌细胞不同。超微结构提示细胞起源可能是肺间质细胞而非血管平滑肌。这些细胞也有可能来源于周细胞。在增殖细胞中可见糖原蓄积，提示这是雌激素占优势的一种表现。
