Adler K B, Craighead J E, Vallyathan N V, Evans J N
Am J Pathol. 1981 Mar;102(3):427-37.
Lung tissue from five patients with varying degrees of diffuse pulmonary fibrosis was examined for the presence of nonmuscle cells containing the contractile protein actin. Histochemical studies using light- and electron-microscopic techniques suggested that the fibrotic tissue, in areas lacking smooth muscle, had within it numerous cells with cytoplasmic microfilaments composed of actin. Similar cells rarely were observed in control lung tissue. The orientation of these cells within the parenchyma, as well as the arrangement and density of the filaments in the cell, suggests a contractile function. Cells with contractile properties might play a role in the altered dynamics of the lung in diffuse fibrotic pulmonary disease.
对五名患有不同程度弥漫性肺纤维化患者的肺组织进行检查，以确定是否存在含有收缩蛋白肌动蛋白的非肌细胞。使用光学显微镜和电子显微镜技术进行的组织化学研究表明，在缺乏平滑肌的区域，纤维化组织中有许多细胞含有由肌动蛋白组成的细胞质微丝。在对照肺组织中很少观察到类似的细胞。这些细胞在实质内的取向以及细胞内细丝的排列和密度表明其具有收缩功能。具有收缩特性的细胞可能在弥漫性纤维化肺病中肺动力学改变中起作用。
