Stadel B V
Lancet. 1976 Apr 24;1(7965):890-1. doi: 10.1016/s0140-6736(76)92102-4.
Geographic differences in the rates of breast, endometrial, and ovarian cancer appear to be inversely correlated with dietary iodine intake. Endocrinological considerations suggest that a low dietary iodine intake may produce a state of increased effective gonadotrophin stimulation, which in turn may produce a hyperoestrogenic state characterised by relatively high production of oestrone and oestradiol and a relatively low oestriol to oestrone plus oestradiol ratio. This altered endocrine state may increase the risk of breast, endometrial, and ovarian cancer. Increasing dietary iodine intake may reduce the risk of these cancers.
乳腺癌、子宫内膜癌和卵巢癌的发病率存在地理差异，这似乎与饮食中碘的摄入量呈负相关。从内分泌学角度考虑，饮食中碘摄入量低可能会导致有效促性腺激素刺激增加，进而可能产生一种高雌激素状态，其特征是雌酮和雌二醇的产量相对较高，而雌三醇与雌酮加雌二醇的比例相对较低。这种内分泌状态的改变可能会增加患乳腺癌、子宫内膜癌和卵巢癌的风险。增加饮食中碘的摄入量可能会降低这些癌症的风险。
