摄入滴滴涕的奥斯本-孟德尔大鼠的肝癌
Carcinomas of the liver in Osborne-Mendel rats ingesting DDT.
作者信息
Reuber M D
出版信息
Tumori. 1978 Nov-Dec;64(6):571-7. doi: 10.1177/030089167806400603.
PMID:581710
Abstract
Osborne-Mendel male and female rats ingested 200, 400, 600, or 800 ppm DDT composed of 81.8% p,p isomer and 18.2% o,p isomer for periods up to 2 years. Male and female rats developed highly significant incidences of hepatocellular carcinomas. The carcinomas varied from well-differentiated to undifferentiated. There was a highly significant increase in carcinomas of the ovary in treated female rats. Lymphosarcomas were also increased in DDT-treated male rats.
摘要
奥斯本-孟德尔品系的雄性和雌性大鼠摄入了含81.8%对，对异构体和18.2%邻，对异构体的滴滴涕，浓度分别为200、400、600或800 ppm，持续时间长达2年。雄性和雌性大鼠肝细胞癌的发病率都非常高。这些癌从高分化到未分化不等。在接受治疗的雌性大鼠中，卵巢癌有极显著的增加。在接受滴滴涕治疗的雄性大鼠中，淋巴肉瘤也有所增加。
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