Taylor P, Schoene W C, Reid W A, von Lichtenberg F
Arch Pathol Lab Med. 1979 Feb;103(2):82-5.
Chimpanzees without liver cell damage, but subjected to portacaval anastomosis, showed behavioral changes that were accompanied by "Alzheimer II" astrocyte hyperplasia and nuclear enlargement. These findings were similar to those in a human patient with encephalopathy, secondary to a portacaval shunt, whose liver was normal. Controlled quantitative study of astrocytic hyperplasia in different anatomic regions showed the hyperplasia to involve the gray matter with only moderate topographic variation. Individual degrees of hyperplasia somewhat paralleled the severity of clinical symptoms and ammonia levels; no clear-cut relationship with time after shunting could be established. Portacaval shunt encephalopathy in chimpanzees greatly resembles that in man and, thus, lends itself to more detailed experimental analysis.
未出现肝细胞损伤但接受了门腔静脉吻合术的黑猩猩表现出行为变化，同时伴有“阿尔茨海默II型”星形胶质细胞增生和细胞核增大。这些发现与一名因门腔分流继发脑病但肝脏正常的人类患者的情况相似。对不同解剖区域星形胶质细胞增生的对照定量研究表明，增生累及灰质，且仅有适度的局部差异。个体增生程度在一定程度上与临床症状的严重程度和氨水平平行；与分流后的时间没有明确的关系。黑猩猩的门腔分流性脑病与人类的极为相似，因此适合进行更详细的实验分析。
