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大鼠门腔分流和门腔转位后星形胶质细胞核的变化。

Changes in the nuclei of astrocytes following portacaval shunting and portacaval transposition in the rat.

作者信息

Doyle D, Ryan C J, Benjamin I S, Blumgart L H

出版信息

Br J Exp Pathol. 1978 Oct;59(5):461-6.

Abstract

Structural abnormalities are found in the astrocytes of the dentate nuclei of animals after portacaval shunting (PCS). These changes are also found in man in association with portal-systemic encephalopathy. To investigate the relationship between portal-systemic shunting and hepatocellular dysfunction in the pathogenesis of these changes, PCS and protacaval transposition (PCT) were performed in rats. PCT diverts portal blood into the systemic circulation, but retains normal total hepatic blood flow by perfusion with systemic venous blood. Liver function and mass are better preserved than after PCS. Abnormal glial cells were found in 4.03% of animals following sham operation, 13.45% following PCT, and 19.09% following PCS. Both experimental groups differed significantly from control animals, and the number of abnormal cells was significantly higher after PCS than after PCT. These findings are in keeping with the hypothesis that hepatocellular dysfunction plays an important role in addition to portal-systemic shunting in the aetiology of the structural changes in the brain associated with hepatic encephalopathy.

摘要

门腔分流术(PCS)后,动物齿状核星形胶质细胞出现结构异常。在人类中,这些变化也与门体性脑病有关。为了研究门体分流与肝细胞功能障碍在这些变化发病机制中的关系,对大鼠进行了PCS和门腔静脉转位术(PCT)。PCT将门静脉血分流至体循环,但通过体循环静脉血灌注保持正常的肝脏总血流量。与PCS后相比,肝功能和肝脏质量得到更好的保留。假手术后4.03%的动物、PCT后13.45%的动物以及PCS后19.09%的动物发现有异常神经胶质细胞。两个实验组与对照动物均有显著差异,且PCS后异常细胞数量显著高于PCT后。这些发现符合以下假设:在与肝性脑病相关的脑部结构变化病因中,除门体分流外,肝细胞功能障碍也起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388c/2041380/b4974b334297/brjexppathol00131-0024-a.jpg

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