Heimann G, Mensah-Kordieh J, Roth B, Gladtke E
Arzneimittelforschung. 1978;28(5):861-4.
After intravenous and oral application of 25 mg 6-(sulfanilamido)-2,4-dimethyl-pyrimidine (sulfasomidin)/kg body-weight to 29 newborns, 8 infants and 9 older children the completeness and rate of absorption were determined. Sulfasomidine was completely absorbed in newborns (mean value 95.7%) as well as in older children (mean value 94.4%). Concerning the rate of absorption there were age-dependent differences. Using the Bateman function for the kinetic model of intestinal absorption the rate constant of invasion k1 was significantly lower in the first week of life compared to that in older children. In agreement with these data the time tmax of the maximum serum concentration was significantly prolonged in newborns compared to that of older children.
给29名新生儿、8名婴儿和9名大龄儿童静脉注射和口服25毫克6-（磺胺氨基）-2,4-二甲基嘧啶（磺胺索嘧啶）/千克体重后，测定其吸收的完整性和速率。磺胺索嘧啶在新生儿（平均值95.7%）和大龄儿童（平均值94.4%）中均被完全吸收。关于吸收速率，存在年龄依赖性差异。使用贝特曼函数作为肠道吸收动力学模型，与大龄儿童相比，出生后第一周的侵入速率常数k1显著更低。与这些数据一致，新生儿血清最大浓度的达峰时间tmax比大龄儿童显著延长。
