Lang A, Geissler H E, Mutschler E
Arzneimittelforschung. 1979;29(1):154-7.
The (+) and (-)isomers of DL-trans-2-phenylcyclopropylamine (tranylcypromine, Parnate, Jatrosom) were tested under cross-over conditions on 10 volunteers. (-)Tranylcypromine entered blood circulation more rapidly, reached significantly higher concentrations and was metabolized more slowly than (+)tranylcypromine. These results indicate a difference in the pharmacokinetics of the tranylcypromine isomers. In the urine collected over a period of 24 h the excretion of unmetabolized (4)tranylcypromine was lower probably resulting from the greater metabolization rate of this isomer. There is a conformity between the findings in plasma and urine.
在交叉试验条件下，对10名志愿者测试了DL - 反式 - 2 - 苯基环丙胺（反苯环丙胺，帕罗西汀，贾特罗索姆）的（+）和（ - ）异构体。（ - ）反苯环丙胺进入血液循环的速度更快，达到的浓度显著更高，并且比（+）反苯环丙胺代谢更慢。这些结果表明反苯环丙胺异构体在药代动力学上存在差异。在24小时收集的尿液中，未代谢的（4）反苯环丙胺排泄量较低，这可能是由于该异构体的代谢率较高所致。血浆和尿液中的研究结果是一致的。
