人体内放射性碘化人生长激素的代谢清除率
Metabolic clearance rate of radioiodinated human growth hormone in man.
作者信息
Cameron D P, Burger H G, Catt K J, Doig A
出版信息
J Clin Invest. 1969 Sep;48(9):1600-8. doi: 10.1172/JCI106125.
Abstract
The nature of the disappearance of radioiodinated human growth hormone (HGH) from plasma has been reexamined. The metabolic clearance rate (MCR) was determined both from single injection and constant infusion studies. After single injection of highly purified radioiodinated HGH, the disappearance curve remained multiexponential during the period of study (4 hr). The shape of the curve was independent of the growth hormone preparation used. Similar disappearance curves were obtained with unlabeled HGH.MCR values calculated from constant infusion studies were 203 +/-7.8 liters/day per m(2) and values derived from single injection studies agreed closely with this. The multiexponential nature of the disappearance curve does not permit meaningful calculation of volume of distribution or half-time of disappearance.
摘要
已对放射性碘化人生长激素（HGH）从血浆中消失的性质进行了重新研究。通过单次注射和持续输注研究测定了代谢清除率（MCR）。单次注射高度纯化的放射性碘化HGH后，在研究期间（4小时）消失曲线仍为多指数曲线。曲线形状与所用的生长激素制剂无关。未标记的HGH也得到了类似的消失曲线。通过持续输注研究计算出的MCR值为每平方米203±7.8升/天，单次注射研究得出的值与此非常接近。消失曲线的多指数性质不允许对分布容积或消失半衰期进行有意义的计算。
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