肥胖中的膈肌活动
Diaphragm activity in obesity.
作者信息
Lourenço R V
出版信息
J Clin Invest. 1969 Sep;48(9):1609-14. doi: 10.1172/JCI106126.
Abstract
DIAPHRAGM ACTIVITY DURING CARBON DIOXIDE BREATHING AND TOTAL CHEST COMPLIANCE DURING DIAPHRAGM RELAXATION WERE MEASURED IN EIGHT OBESE SUBJECTS
four with normal blood gases and four with hypercapnia and hypoxemia. Whereas there were no significant differences in the values of total chest compliance between the two groups, there were marked differences in diaphragm activity. The increase in integrated electrical activity in the diaphragm, per millimeter increment in carbon dioxide tension in the arterial blood, averaged 66 units (range: 48-90) in the obese-normal subjects and 17 units (range: 12-22) in the obese-hypoventilation subjects. These results suggest that an incapacity to increase the activity in the respiratory muscles, to levels necessary to overcome the load caused by obesity, plays a major role in the genesis of respiratory failure in obese subjects.
摘要
在八名肥胖受试者中测量了二氧化碳呼吸期间的膈肌活动以及膈肌松弛期间的全胸顺应性
四名血气正常，四名患有高碳酸血症和低氧血症。虽然两组之间的全胸顺应性值没有显著差异，但膈肌活动存在明显差异。在肥胖-正常受试者中，动脉血二氧化碳张力每增加一毫米，膈肌综合电活动的增加平均为66个单位（范围：48-90），而在肥胖-通气不足受试者中为17个单位（范围：12-22）。这些结果表明，呼吸肌无法将活动增加到克服肥胖引起的负荷所需的水平，在肥胖受试者呼吸衰竭的发生中起主要作用。
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