Clark T J, Cochrane G M
Br Med J. 1972 Feb 5;1(5796):351-3. doi: 10.1136/bmj.1.5796.351.
The ventilatory response to CO(2) (S) and respiratory exchange ratio have been measured in 10 healthy subjects breathing naturally and through added resistive loads. The changes in these values produced by the added loads were shown to be correlated with the unloaded CO(2) responsiveness. The results indicated that poorly responsive individuals had a greater depression of ventilatory response to CO(2) and were more liable to retain CO(2).These observations raise the possibility that the constitutional CO(2) responsiveness of an individual influences the alveolar ventilation achieved in the presence of airways obstruction. The propensity to develop respiratory failure may thus be conditioned by the premorbid CO(2) responsiveness.
在10名健康受试者自然呼吸以及通过增加呼吸阻力负荷呼吸的情况下，测量了对二氧化碳的通气反应（S）和呼吸交换率。结果显示，增加负荷所导致的这些数值变化与无负荷时的二氧化碳反应性相关。结果表明，反应性较差的个体对二氧化碳的通气反应抑制程度更大，且更易潴留二氧化碳。这些观察结果提示，个体的先天性二氧化碳反应性可能会影响在存在气道阻塞时所达到的肺泡通气。因此，发生呼吸衰竭的倾向可能受病前二氧化碳反应性的制约。
