Kirichuk V F
Probl Endokrinol (Mosk). 1979 May-Jun;25(3):27-31.
Blood coagulation system and fibrinolysis factors contained in the thyroid gland tissue of patients with diffuse toxic and euthyroid goiter and also of apparently healthy persons were investigated. The thyroid gland of healthy persons was shown to possess thromboplastin, antithrombin, anticoagulant, antiheparin, and fibrinolytic properties and to contain plasminogen, plasminogen activators, antiplasmins. The function of the external hemocoagulation system was reduced due to diminished thromboplastin and antiheparin activity of the gland tissue, reduction of aggregation and increase of disaggregation properties of the gland tissue. External blood coagulation system was undisturbed in patients with euthyroid gland. Local fibrinolysis was enhanced in patients with diffuse toxic goiter on account of increase in the thyroid gland of plasminogen activators, reduction of antiplasmin activity, and increase of the nonenzymatic fibrinolysis activity. Analogous changes in local fibrinolysis occurred in patients with euthyroid goiter.
对弥漫性毒性甲状腺肿、甲状腺功能正常的甲状腺肿患者以及明显健康人的甲状腺组织中的血液凝固系统和纤维蛋白溶解因子进行了研究。结果表明，健康人的甲状腺具有凝血活酶、抗凝血酶、抗凝剂、抗肝素和纤维蛋白溶解特性，并含有纤溶酶原、纤溶酶原激活剂和抗纤溶酶。由于甲状腺组织中凝血活酶和抗肝素活性降低、甲状腺组织聚集性降低和分散性增加，导致外源性血液凝固系统功能降低。甲状腺功能正常的患者外源性血液凝固系统未受干扰。弥漫性毒性甲状腺肿患者由于甲状腺中纤溶酶原激活剂增加、抗纤溶酶活性降低和非酶促纤维蛋白溶解活性增加，局部纤维蛋白溶解增强。甲状腺功能正常的甲状腺肿患者也发生了局部纤维蛋白溶解的类似变化。
