Calil H M, Zwicker A P
Psychiatry Res. 1987 Aug;21(4):337-48. doi: 10.1016/0165-1781(87)90017-5.
Plasma prolactin (PRL) and growth hormone (GH) were serially measured over a 5-hour morning period in healthy subjects who twice received a single oral dose of 100 mg desipramine (DMI). The study was carried out both after a regular night of sleep and after 1 night of total sleep deprivation. Clinical studies have suggested that sleep deprivation could potentiate the therapeutic effects of antidepressants, and there were reports on DMI stimulation of GH. The basal PRL levels decreased after sleep deprivation, but subsequently increased after DMI, whereas the same dose of DMI did not affect PRL in the absence of after DMI, whereas the same dose of DMI did not affect PRL in the absence of sleep deprivation. The GH levels increased substantially (8- to 10-fold) after DMI in both experimental conditions. Sleep deprivation neither changed GH basal levels nor potentiated the DMI-induced GH increase.
在健康受试者中，于早晨5小时期间连续测量血浆催乳素（PRL）和生长激素（GH），这些受试者两次接受单次口服100毫克去甲丙咪嗪（DMI）。该研究在正常睡眠一晚后以及完全睡眠剥夺一晚后均进行。临床研究表明，睡眠剥夺可能增强抗抑郁药的治疗效果，并且有关于DMI刺激GH的报道。睡眠剥夺后基础PRL水平降低，但随后在服用DMI后升高，而相同剂量的DMI在没有睡眠剥夺的情况下对PRL没有影响。在两种实验条件下，服用DMI后GH水平均大幅升高（8至10倍）。睡眠剥夺既未改变GH基础水平，也未增强DMI诱导的GH升高。
