Porsius A J, Mutschler E, Van Zwieten P A
Arzneimittelforschung. 1978;28(8):1373-6.
The central action of various arecaidine esters (arecoline derivatives) on the cardiovascular system has been studied. Central injection of these cholinergic drugs into the vertebral artery of the cat gives rise to a hypotensive effect, whereas heart rate is not affected. It is concluded that the blood pressure lowering effect is brought about by stimulating central muscarinic receptors. Moreover, the experimental results indicate that the central muscarinic receptors behave in the same way towards their agonists as do the peripheral muscarinic receptors.
已对多种槟榔次碱酯（槟榔碱衍生物）对心血管系统的中枢作用进行了研究。将这些胆碱能药物经椎动脉向猫的中枢注射会产生降压作用，而心率不受影响。得出的结论是，血压降低效应是通过刺激中枢毒蕈碱受体产生的。此外，实验结果表明，中枢毒蕈碱受体对其激动剂的反应方式与外周毒蕈碱受体相同。
