Porsius A J, Van Zwieten P A
Arzneimittelforschung. 1978;28(9):1628-31.
After injection into the vertebral artery of anaesthetized cats, low does of nicotine (10(-9)--10(-8) mol = 0.5--5 micrograms . kg-1) induce potent cardiovascular effects. The hypotensive action is always accompanied by a severe bradycardia. Dose-response curves for these pharmacological actions have been established. It is concluced that nicotinic receptors in the medulla oblongata and pons are involved. Administration of 10(-8) mol = 5 micrograms (radioactive) nicotine/kg into the left vertebral artery gives rise to a specific distribution pattern. Nicotine mainly accumulates into the ponto-medullary area, whereas higher brain regions (hypothalamus) contain only insignificant amounts. The experimental results suggest that the nicotine-like effect of endogenous acetylcholine might play an important physiological part in the central regulation of blood pressure and cardiac frequency.
给麻醉猫的椎动脉注射后，低剂量的尼古丁（10⁻⁹ - 10⁻⁸摩尔 = 0.5 - 5微克·千克⁻¹）会引起强烈的心血管效应。降压作用总是伴随着严重的心动过缓。已经建立了这些药理作用的剂量反应曲线。得出的结论是，延髓和脑桥中的烟碱受体参与其中。向左椎动脉注射10⁻⁸摩尔 = 5微克（放射性）尼古丁/千克会产生特定的分布模式。尼古丁主要积聚在脑桥延髓区域，而较高的脑区（下丘脑）含量极少。实验结果表明，内源性乙酰胆碱的尼古丁样作用可能在血压和心率的中枢调节中起重要的生理作用。
