Hadjigeorgiou E, Kitsiou S, Psaroudakis A, Segos C, Nicolopoulos D, Kaskarelis D
Am J Obstet Gynecol. 1979 Sep 15;135(2):257-60. doi: 10.1016/0002-9378(79)90355-7.
The frequency of idiopathic respiratory distress (IRD) among premature offspring born of women who were given aminophylline before the thirty-fourth week of pregnancy was evaluated. Sixty-seven premature deliveries were included in the aminophylline group and 75 in the control group. The perinatal death rate was 7.1% in the aminophylline group and 17.9% in the control group (p less than 0.05). A statistically significant difference was noted between the aminophylline and control groups in the frequency of IRD which was three times lower (10%) in the aminophylline group than in the control group (29.5%) for the total of premature infants. If the time of rupture of membranes is taken into consideration, a significant decrease in the frequency of IRD following aminophylline administration is noted in the infants, whose mothers had ruptured membranes for more than 24 hours. No complications or side effects of aminophylline administration were noted in the mothers or their infants.
对怀孕34周前接受氨茶碱治疗的女性所生早产后代中特发性呼吸窘迫（IRD）的发生率进行了评估。氨茶碱组纳入67例早产分娩，对照组纳入75例。氨茶碱组围产期死亡率为7.1%，对照组为17.9%（p<0.05）。氨茶碱组和对照组在IRD发生率方面存在统计学显著差异，氨茶碱组中早产婴儿的IRD发生率（10%）比对照组（29.5%）低三倍。如果考虑胎膜破裂时间，在母亲胎膜破裂超过24小时的婴儿中，氨茶碱给药后IRD发生率显著降低。在母亲或其婴儿中未观察到氨茶碱给药的并发症或副作用。
