Caspi E, Schreyer P, Reif R, Goldberg M
Br J Obstet Gynaecol. 1980 Sep;87(9):808-13. doi: 10.1111/j.1471-0528.1980.tb04617.x.
The incidence of respiratory distress syndrome (RDS) in 259 premature infants whose 218 mothers had received antepartum dexamethasone therapy was 8.9 per cent. The main characteristics of those infants who developed RDS were a shorter gestational age and a lower Apgar score at delivery; all were delivered before 35 weeks gestation, and those with Apgar scores below 7 had a significantly higher incidence of RDS. The incidence of RDS in vaginal breech deliveries (15.4 per cent), Caesarean sections (14.6 per cent), and multiple births (16.0 per cent) was higher than in vaginal vertex deliveries (6.8 percent), and in singletons (6.0 per cent). The use of isoxsuprine and the length of time membranes were ruptured before delivery were unrelated to the incidence of RDS. The results of this study suggest that while maternal glucocorticoid administratioin is an important ancillary to the prevention of RDS in premature infants it cannot substitute for optimal delivery conditions.
218名母亲在产前接受地塞米松治疗的259名早产儿中，呼吸窘迫综合征（RDS）的发生率为8.9%。发生RDS的婴儿的主要特征是胎龄较短和出生时阿氏评分较低；所有婴儿均在妊娠35周前出生，阿氏评分低于7分的婴儿RDS发生率明显更高。臀位阴道分娩（15.4%）、剖宫产（14.6%）和多胎分娩（16.0%）时RDS的发生率高于头位阴道分娩（6.8%）和单胎分娩（6.0%）。使用异克舒令以及分娩前胎膜破裂时间与RDS的发生率无关。这项研究的结果表明，虽然母体糖皮质激素给药是预防早产儿RDS的一项重要辅助措施，但它不能替代最佳的分娩条件。
