5-乙基-2'-脱氧尿苷（EDU）对大鼠白血病L 5222中环磷酰胺（CPA）化疗效果无增强作用（作者译）
[No increase in chemotherapeutic effectiveness of cyclophosphamide (CPA) in rat leukemia L 5222 by 5-ethyl-2'-deoxyuridine (EDU) (author's transl)].
作者信息
Zeller W J, Schmähl D
出版信息
Arzneimittelforschung. 1978;28(9):1564-6.
PMID:582556
Abstract
Monotherapy of early rat leukemia L 5222 with 5 X 100 mg/kg EDU over 48 h yielded no increase in lifespan as compared to untreated controls. Combination therapy of advanced L 5222 with EDU and CPA in four different schedules results in no increase in life-span as compared to treatment with CPA only. DNA histogrms of preterminal L 5222 revealed no synchronizing effect of EDU.
摘要
早期大鼠白血病L 5222在48小时内以5×100毫克/千克的EDU进行单一疗法，与未治疗的对照组相比，寿命没有增加。晚期L 5222采用EDU和CPA进行四种不同方案的联合治疗，与仅用CPA治疗相比，寿命没有增加。终末期前L 5222的DNA直方图显示EDU没有同步作用。
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