Zeller W J, Berger M, Eisenbrand G, Tang W, Schmähl D
Arzneimittelforschung. 1982;32(5):484-6.
The therapeutic activity of a single-dose treatment with 14 2-chloroethylnitrosocarbamoyl derivatives of amino acids (CNU-analogs) in L 5222 rat leukemia is presented. Compounds under study included free carboxylic acids, a methylester, a toluidide, four glucosamides and one derivative of a dipeptide. All substances proved to be active effecting at least an increase in life span of greater than or equal to 120% compared with untreated controls at the optimal dose; 2 compounds effected isolated cures (90-day survivors). Compared with previous data obtained with established and new nitrosoureas under the same conditions, the effectivity of the compounds presented here should be classified, however, only as moderate.
本文介绍了用14种氨基酸的2-氯乙基亚硝基氨基甲酰衍生物（CNU类似物）进行单剂量治疗对L 5222大鼠白血病的治疗活性。所研究的化合物包括游离羧酸、甲酯、甲苯胺、四种葡糖酰胺和一种二肽衍生物。所有物质均被证明具有活性，在最佳剂量下，与未治疗的对照组相比，至少使寿命延长120%以上；有2种化合物实现了个别治愈（存活90天）。然而，与在相同条件下用已有的和新的亚硝基脲获得的先前数据相比，本文所展示化合物的有效性只能归类为中等。
