Chemotherapeutic activity of 2-chloroethylnitrosocarbamoyl derivatives of amino acids in a transplanted rat leukemia (L 5222).

The therapeutic activity of a single-dose treatment with 14 2-chloroethylnitrosocarbamoyl derivatives of amino acids (CNU-analogs) in L 5222 rat leukemia is presented. Compounds under study included free carboxylic acids, a methylester, a toluidide, four glucosamides and one derivative of a dipeptide. All substances proved to be active effecting at least an increase in life span of greater than or equal to 120% compared with untreated controls at the optimal dose; 2 compounds effected isolated cures (90-day survivors). Compared with previous data obtained with established and new nitrosoureas under the same conditions, the effectivity of the compounds presented here should be classified, however, only as moderate.