1-（2-氯乙基）-3-环己基-1-亚硝基脲（CCNU）与环磷酰胺（CPA）以及甲基CCNU与CPA联合用于移植大鼠白血病L 5222的化疗（作者译）
[Combination chemotherapy of transplanted rat leukemia L 5222 with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and cyclophosphamide (CPA) as well as with methyl-CCNU and CPA (author's transl)].
作者信息
Zeller W J, Berger M
出版信息
Arzneimittelforschung. 1981;31(2):303-5.
PMID:7194646
Abstract
The acute transplanted rat leukemia L 5222 was used to investigate the two-drug combinations 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and cyclophosphamide (CPA) as well as methyl-CCNU and CPA. A therapeutic synergism could not be demonstrated in either combination. In both combinations the monotherapy with the nitrosourea was superior to the combination as well as to the monotherapy with CPA.
摘要
采用急性移植大鼠白血病L 5222来研究两种药物组合，即1-(2-氯乙基)-3-环己基-1-亚硝基脲（CCNU）与环磷酰胺（CPA）以及甲环亚硝脲与CPA。两种组合均未显示出治疗协同作用。在这两种组合中，亚硝基脲单药治疗均优于联合治疗以及CPA单药治疗。
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