Fiedler V B, Scholtholt J
Arzneimittelforschung. 1978;28(9):1605-12.
The haemodynamic effects of N-carboxy-3-morpholino-sydronimine-ethylester (molsidomine, SIN 10, Corvaton) were studied in anaesthetized mongrel dogs. The effects of molsidomine were identical when given i.v. or i.d. Because of the lack of difference in activity with similar doses i.v. or i.d. complete absorption of the drug can be assumed. There was a sustained decrease in arterial blood pressure accompanied by a long lasting decrease in left ventricular enddiastolic and mean pulmonary artery blood pressure. Heart rate was only moderately affected. Left ventricular endsystolic and enddiastolic volumes, as estimated from measurements of left ventricular outer dimension with ultrasonic techniques, decreased. Even in nearly toxic doses molsidomine did not influence left ventricular contractility as judge from measurements of dp/dt max., (dp/dt)/(LVP-LVEDP + c) max., ejection time and duration of systole. All the observed effects of molsidomine can be explained by an extracardiac action: increase in systemic venous capacity. Consequently venous return, mean pulmonary artery pressure and left ventricular filling pressure are reduced leading to a decrease in left ventricular volumes. This should cause a reduction of cardiac output, of peripheral blood pressure and of external cardiac work. In connection with reduced left ventricular wall tension a fall in myocardial oxygen consumption can be expected.
在麻醉的杂种犬中研究了N-羧基-3-吗啉代西多明乙酯（莫西多明，SIN 10，可洛丁）的血流动力学效应。静脉注射或皮内注射莫西多明时，其效应相同。由于静脉注射或皮内注射相似剂量时活性无差异，因此可以假定药物完全吸收。动脉血压持续下降，同时左心室舒张末期和平均肺动脉血压长期下降。心率仅受到中度影响。根据超声技术测量的左心室外部尺寸估算，左心室收缩末期和舒张末期容积减小。即使在接近中毒剂量时，根据dp/dt max.、(dp/dt)/(LVP-LVEDP + c) max.、射血时间和收缩期持续时间的测量判断，莫西多明也不影响左心室收缩力。莫西多明所有观察到的效应都可以通过心外作用来解释：全身静脉容量增加。因此，静脉回流、平均肺动脉压和左心室充盈压降低，导致左心室容积减小。这将导致心输出量、外周血压和心脏外部功降低。与左心室壁张力降低相关，预计心肌耗氧量会下降。
