Fiedler V B, Buchheim S, Scholtholt J
Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):201-4. doi: 10.1007/BF00506322.
Measurements of intracranial liquor pressure were made during i.v. molsidomine administration in pentobarbital anaesthetized beagle dogs without thoracotomy, and compared with those after nitroglycerin. The administration of 100 micrograms/kg molsidomine decreased blood pressure by 14 mmHg and increased intracranial pressure by 3.7 cm H2O (P less than 0.05). No changes in heart rate and the alveolar end-tidal CO2 concentration were noted. The i.v. administration of 5 micrograms/kg nitroglycerin, however, decreased systolic blood pressure by 41 mmHg (p less than 0.05), increased heart rate by 40 bpm (p less than 0.01), elevated intracranial pressure by 3.2 cm H2O (p less than 0.05), and caused marked hyperventilation indicated by increased end-tidal CO2 concentration. Larger increases in intracranial pressure were related to larger pressure reductions. Thus, molsidomine produced significant increase in intracranial liquor pressure of longer duration (60 to 90 min of observation time). Nitroglycerin increased liquor pressure with a short duration of action and was about twenty time more effective with respect to intracranial pressure increase. In contrast to molsidomine, this was accompanied by significant decrease in systolic peripheral blood pressure.
在戊巴比妥麻醉且未开胸的比格犬静脉注射吗多明期间测量颅内液压力，并与注射硝酸甘油后的情况进行比较。静脉注射100微克/千克吗多明可使血压降低14 mmHg，并使颅内压升高3.7 cmH₂O（P<0.05）。未观察到心率和肺泡呼气末二氧化碳浓度有变化。然而，静脉注射5微克/千克硝酸甘油可使收缩压降低41 mmHg（P<0.05），使心率增加40次/分钟（P<0.01），使颅内压升高3.2 cmH₂O（P<0.05），并导致以呼气末二氧化碳浓度增加为指标的明显过度通气。颅内压升高幅度越大与血压降低幅度越大相关。因此，吗多明使颅内液压力显著升高且持续时间更长（观察时间60至90分钟）。硝酸甘油使液压力升高且作用持续时间短，就颅内压升高而言其效力约是吗多明的20倍。与吗多明相反，这伴随着收缩期外周血压显著降低。
