给予口服胆囊造影剂碘番酸（Oragrafin）的甲状腺功能正常和甲状腺功能亢进受试者循环甲状腺原氨酸的变化。

Changes in circulating iodothyronines in euthyroid and hyperthyroid subjects given ipodate (Oragrafin), an agent for oral cholecystography.

作者信息

Wu S Y, Chopra I J, Solomon D H, Bennett L R

出版信息

J Clin Endocrinol Metab. 1978 Apr;46(4):691-7. doi: 10.1210/jcem-46-4-691.

Abstract

A dose (3 g) of sodium ipodate used routinely in oral cholecystography caused a fall in serum 3,5,3'-triiodothyronine and a rise in serum 3,3',5'-triiodothyronine in three patients taking thyroxine (T4), four euthyroid subjects,and four hyperthyroid patients. Serum T4 fell in patients with hperthyroidism, whereas it rose in the other two groups. Sodium ipodate appears to alter peripheral T4 metabolism and, in addition, produces thyroid-inhibiting effects in hyperthyroidism.

摘要

口服胆囊造影术中常规使用的一剂（3克）碘泊酸钠，导致3例服用甲状腺素（T4）的患者、4例甲状腺功能正常者和4例甲状腺功能亢进患者的血清3,5,3'-三碘甲状腺原氨酸水平下降，血清3,3',5'-三碘甲状腺原氨酸水平上升。甲状腺功能亢进患者的血清T4水平下降，而其他两组患者的血清T4水平上升。碘泊酸钠似乎会改变外周T4代谢，此外，对甲状腺功能亢进有甲状腺抑制作用。