Flint D J, Ensor D M
J Reprod Fertil. 1979 Jul;56(2):691-6. doi: 10.1530/jrf.0.0560691.
Ergocryptine (2 mg/kg) caused short- and long-term reduction of prolactin secretion in rats experiencing concurrent lactation and pregnancy. The long-term effects of the drug lasted at least 60 days and resulted in reduced milk secretion and termination of pregnancy. Prolactin replacement therapy at a low dose (5 i.u./day) was unsuccessful in overcoming these effects but a higher dose (up to 60 i.u./day) increased milk production and maintained pregnancy. One possible explanation of these results is that prolactin, rather than the suckling stimulus, was responsible for the suppression of oestrous cycles, because ergocryptine brought about a resumption of oestrous vaginal smears in all treated rats in spite of continued suckling.
麦角隐亭（2毫克/千克）可使同时处于泌乳期和妊娠期的大鼠的催乳素分泌出现短期和长期减少。该药物的长期作用至少持续60天，导致乳汁分泌减少和妊娠终止。低剂量（5国际单位/天）的催乳素替代疗法未能克服这些影响，但较高剂量（高达60国际单位/天）可增加乳汁分泌并维持妊娠。这些结果的一种可能解释是，催乳素而非哺乳刺激是抑制发情周期的原因，因为尽管持续哺乳，但麦角隐亭仍使所有接受治疗的大鼠的阴道涂片恢复发情。
