Brown J J, Lever A F, Robertson J I
Lancet. 1976 Jun 5;1(7971):1217-9. doi: 10.1016/s0140-6736(76)92164-4.
It is proposed that essential hypertension is an exaggeration of the tendency for blood-pressure to rise with age, that it results from a repeated sequence in which a small rise in pressure, possibly resulting from an autonomic nervous overactivity, produces changes in the kidney which maintain the rise of pressure and become the basis for a further rise.
