Hofman A, Boomsma F, Schalekamp M A, Valkenburg H A
Br Med J. 1979 Jun 9;1(6177):1536-8. doi: 10.1136/bmj.1.6177.1536.
Plasma noradrenaline (PNA) concentrations were measured in 38 subjects aged 13-23, who were followed up for two to four years after an initial blood-pressure (BP) reading of 140/90 mm Hg or over was obtained, and in 39 age-matched controls from the same open population. Subjects who were hypertensive when the PNA concentration was measured had a significantly higher concentration (351 +/- SE 26 pg/ml) compared with their controls (248 +/- 29 pg/ml). Furthermore, in those subjects in whom the mean arterial pressure decreased by under 5% during the follow-up period the mean concentration was 363 +/- 27 pg/ml, compared with 271 +/- 29 pg/ml in their controls. PNA concentrations and systolic BP were positively correlated. A positive association between PNA concentrations and age was observed in the controls but not the subjects with hypertension, owing to the higher concentrations in younger hypertensive subjects.
对38名年龄在13至23岁之间的受试者测量了血浆去甲肾上腺素（PNA）浓度，这些受试者在首次测得血压（BP）为140/90 mmHg或更高后，进行了两到四年的随访，并与来自同一开放人群的39名年龄匹配的对照者进行了比较。在测量PNA浓度时患有高血压的受试者，其浓度（351±标准误26 pg/ml）显著高于其对照者（248±29 pg/ml）。此外，在随访期间平均动脉压下降不到5%的受试者中，平均浓度为363±27 pg/ml，而其对照者为271±29 pg/ml。PNA浓度与收缩压呈正相关。在对照者中观察到PNA浓度与年龄呈正相关，但在高血压受试者中未观察到，这是由于年轻高血压受试者的浓度较高。
