Brown J J, Davies D L, Morton J J, Robertson J I, Cuesta V, Lever A F, Padfield P L, Trust P
Lancet. 1976 Jun 5;1(7971):1219-21. doi: 10.1016/s0140-6736(76)92165-6.
Renal hypertension of the two-kidney type is divided into three stages. In the first, hypertension results from the vasoconstrictor effect of angiotensin II. This persists to some extent in the second phase but there is in addition a slow-developing pressor effect, also resulting from angiotensin II and probably attributable to sodium. In the first two phases removal of the abnormal kidney corrects the hypertension. This fails in the third phase because changes in the opposite kidney maintain hypertension. Renin and angiotensin are probably not involved at this stage.
