ACP（吡哆醇-2-酮戊二酸）对门静脉血流改道后肝衰竭的影响。
Effect of ACP (pyridoxine-2-oxoglutarate) on hepatic failure after diversion of portal blood flow.
作者信息
Garbin L, Plebani M, Vassanelli P, Bertazzon A, Terribile P M
出版信息
Acta Vitaminol Enzymol. 1978;32(1-4):41-9.
PMID:582874
Abstract
The protective effect of pyridoxine-2-oxoglutarate (ACP) was studied in end-to-side porto-caval shunted rats. A significant improvement of hepatic conditions was shown in ACP-treated rats, while an increased mortality was observed in pyridoxine and 2-oxoglutarate treated rats. Serum glutamic-oxaloacetic transminase, glutamicpyruvic transaminase and lactic dehydrogenase activities, composition of serum proteins, liver mitochondria oxygen consumption rate, plasma ammonia were tested.
摘要
研究了吡哆醇 - 2 - 酮戊二酸（ACP）对端侧门腔分流大鼠的保护作用。结果显示，接受ACP治疗的大鼠肝脏状况有显著改善，而接受吡哆醇和2 - 酮戊二酸治疗的大鼠死亡率有所增加。检测了血清谷草转氨酶、谷丙转氨酶和乳酸脱氢酶活性、血清蛋白组成、肝线粒体氧消耗率及血浆氨含量。
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