氨基乙酰丙酸（吡哆醇-2-酮戊二酸）对大鼠四氯化碳中毒及链脲佐菌素诱导的酮症的影响。
Effect of ACP (pyridoxine-2-oxoglutarate) on CCl4 intoxication and in streptozotocin-induced ketosis in rat.
作者信息
Garbin L, Plebani M, Terribile P M
出版信息
Acta Vitaminol Enzymol. 1977;31(6):175-8.
The protective effect of pyridoxine-2-oxoglutarate (ACP) was studied on CCl4-intoxicated rats. A sensitive improvement of hepatic conditions was shown in ACP-treated rats as compared with untreated ones and rats treated with 2-oxoglutarate and pyridoxine. Serum GOT, GPT, OCT activities, composition of serum proteins, liver mitochondria respiratory control index and liver microsomes oxidizing activity were tested. The antiketotic properties of ACP were also demonstrated in Streptozotocin treated rats.
研究了吡哆醇 - 2 - 酮戊二酸（ACP）对四氯化碳中毒大鼠的保护作用。与未处理的大鼠以及用2 - 酮戊二酸和吡哆醇处理的大鼠相比，接受ACP处理的大鼠肝脏状况有明显改善。检测了血清谷草转氨酶（GOT）、谷丙转氨酶（GPT）、鸟氨酸氨基甲酰转移酶（OCT）活性、血清蛋白组成、肝线粒体呼吸控制指数和肝微粒体氧化活性。在链脲佐菌素处理的大鼠中也证实了ACP的抗酮特性。
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