原发性萎缩性甲状腺功能减退症和桥本甲状腺肿中的人类白细胞抗原
HLA in primary atrophic hypothyroidism and Hashimoto goitre.
作者信息
Irvine W J, Gray R S, Morris P J, Ting A
出版信息
J Clin Lab Immunol. 1978 Nov;1(3):193-5.
PMID:583053
Abstract
The prevalence of HLA-B8 was found to be significantly increased in patients with primary atrophic (no goitre) hypothyroidism, but not in goitrous patients with Hashimoto thyroiditis, whether euthroid or hypothroid. There was no correlation between the occurrence of HLA-B8 and the presence of titres of thyroid antibodies at diagnosis or their persistence for at least three years after diagnosis.
摘要
研究发现，原发性萎缩性（无甲状腺肿）甲状腺功能减退患者中HLA - B8的患病率显著升高，但患有桥本甲状腺炎的甲状腺肿患者，无论甲状腺功能正常还是减退，其HLA - B8患病率均未升高。诊断时HLA - B8的出现与甲状腺抗体滴度的存在或诊断后至少三年的持续存在之间没有相关性。
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