Vallée G, Izembart M, Thonnet M
Ann Biol Clin (Paris). 1982;40(6):651-6.
A systematic study of antibodies directed against thyroglobulin on one side, and against microsomes on the other side, was made during two consecutive years on a hospital population of out patients supposed to suffer from a thyroid affection: about one fourth of the serums is positive for at least one of the two antibodies; the benefit of searching antimicrosomal antibodies is capital, but the simultaneous research of thyroglobulin antibodies is necessary. The consequences of this screening are developed in three main pathologic fields: hypothyroidism (real frequency of Hashimoto's disease in spontaneous myxodema); hyperthyroidism (prognostic implications of antibodies presence); normothyroid subjects (screening of clinical thyroid abnormalities).
在连续两年的时间里，针对一家医院中疑似患有甲状腺疾病的门诊患者群体，开展了一项系统性研究，研究一方面针对抗甲状腺球蛋白抗体，另一方面针对抗微粒体抗体：约四分之一的血清中至少有一种抗体呈阳性；检测抗微粒体抗体非常重要，但同时检测甲状腺球蛋白抗体也是必要的。这种筛查的结果在三个主要病理领域进行了阐述：甲状腺功能减退（自发性黏液性水肿中桥本氏病的实际发病率）；甲状腺功能亢进（抗体存在的预后意义）；甲状腺功能正常的受试者（临床甲状腺异常的筛查）。
